Table 1.
Clinical findings and MDSCs
| Clinical characteristics | MDSC ratio ≥22 | MDSC ratio <22 | p value |
|---|---|---|---|
| (n = 39) | (n = 84) | ||
| Age (year) | 68.5 | 70.1 | 0.646 |
| Sex (M/F) | 29/10 | 54/30 | 0.267 |
| AST (IU/l) | 62.0 | 61.5 | 0.543 |
| ALT (IU/l) | 47.1 | 53.9 | 0.759 |
| LDH (IU/l) | 225 | 218 | 0.832 |
| γGTP (IU/l) | 78.0 | 76.0 | 0.252 |
| Platelet (104/μl) | 10.9 | 10.6 | 0.884 |
| Prothrombin time (%) | 75.2 | 82.3 | 0.045 |
| Serum albumin (g/dl) | 3.53 | 3.68 | 0.120 |
| Total bilirubin (mg/dl) | 1.21 | 0.94 | 0.286 |
| WBC (/μl) | 3910 | 3610 | 0.235 |
| Neutrophil (%) | 63.2 | 59.4 | 0.093 |
| Lymphocyte (%) | 26.1 | 29.5 | 0.047 |
| Total cholesterol (mg/dl) | 151 | 149 | 0.926 |
| HbA1c (%) | 5.27 | 5.43 | 0.197 |
| Type IV collagen 7S (ng/ml) | 8.2 | 7.3 | 0.086 |
| DCP (mAU/ml) | 5157 | 432 | 0.561 |
| AFP (ng/ml) | 1301 | 934 | 0.240 |
| Tumor size (mm) | 28.3 | 24.4 | 0.014 |
| Tumor multiplicity (multiple/solitary) | 27/12 | 42/42 | 0.046 |
| TNM stage (I plus II/III plus IV) | 17/22 | 60/24 | 0.003 |
| Child-Pugh (A/B/C) | 20/17/2 | 64/16/4 | 0.015 |
| Etiology (HCV/HBV/others) | 21/11/7 | 61/11/12 | 0.081 |
| CD4+ CD25+ CD127−/low Tregs/CD4+ cells (%) | 7.04 | 6.70 | 0.281 |
AST aspirate aminotransferase, ALT alanine aminotransferase, LDH lactic dehydrogenase, γGTP gamma glutamyltransferase, WBC white blood cell, Hb hemoglobin, DCP des-gamma-prothrombin, AFP alpha-fetoprotein, HCV hepatitis C virus, HBV hepatitis B virus, Tregs regulatory T cells
Chi-squared test with Yates’ correction, unpaired t test, Mann–Whitney U test, and Kruskal–Wallis test were used for univariate analysis of two groups that were classified according to the frequency of MDSCs