Table 2.
Serum cytokines and MDSCs
| Cytokine | Healthy donor (mean) | MDSC ratio ≥ 22 (mean) | Range | MDSC ratio < 22 (mean) | Range | p value |
|---|---|---|---|---|---|---|
| (n = 13) | (n = 21) | (n = 31) | ||||
| IL-1ra | 34.2 | 97.0 | (21.5–600) | 40.3 | (3.4–151) | 0.057 |
| IL-2 | 10.5 | 38.1 | (4.3–54.3) | 11.3 | (0.9–49.7) | 0.055 |
| IL-4 | 2.6 | 5.75 | (1.47–11.9) | 5.03 | (0.71–10.9) | 0.159 |
| IL-6 | 9.9 | 21.5 | (1.2–130) | 10.1 | (0.2–97.2) | 0.065 |
| IL-8 | 24.5 | 64.7 | (10.9–291) | 35.1 | (6.2–142) | 0.156 |
| IL-10 | 2.76 | 6.01 | (0.8–11.5) | 2.81 | (0.1–12.0) | 0.003 |
| IL-12(p70) | 14.6 | 33.3 | (0.6–140) | 17.6 | (1.4–57) | 0.058 |
| IL-13 | 7.6 | 13.1 | (1.2–33.6) | 8.2 | (2.7–22.9) | 0.015 |
| IL-17 | 15.7 | 23.5 | (4.6–70) | 20.8 | (2.1–119) | 0.115 |
| Eotaxin | 104 | 141 | (51.9–493) | 124 | (26.3–331) | 0.675 |
| G-CSF | 7.9 | 13.2 | (2.7–41.3) | 8.7 | (0.5–17.9) | 0.050 |
| IFN-γ | 52.6 | 95.4 | (23.1–417) | 69.9 | (2.5–238) | 0.136 |
| MCP-1 | 20.2 | 26.8 | (8.4–114) | 23.8 | (3.5–77) | 0.744 |
| MIP-1b | 97.6 | 120 | (58.3–490) | 108 | (39.7–263) | 0.508 |
| PDGF | 4012 | 4375 | (1,312–10,136) | 4013 | (831–13,557) | 0.484 |
| RANTES | 2978 | 2890 | (1,040–4,826) | 3184 | (599–6,165) | 0.186 |
| TNF-α | 10.5 | 34.9 | (0.1–175) | 27.6 | (2.9–105) | 0.756 |
| VEGF | 34.6 | 101.7 | (22.5–371) | 59.5 | (9.3–183) | 0.045 |
IL interleukin, G-CSF granulocytic colony stimulating factor, IFN interferon, MCP monocyte chemoattractant protein, MIP macrophage inflammatory protein, PDGF platelet-derived growth factor, RANTES regulated upon activation, normal T cell expressed and secreted, TNF tumor necrosis factor, VEGF vascular endothelial growth factor
Mann–Whitney U test was used for univariate analysis of two groups that were classified according to the frequency of MDSCs