Table 3.
Cox proportional hazards regression for recurrence
| Variant | Univariate HR (95 % CI) | p value | Multivariable HR (95 % CI) | p value |
|---|---|---|---|---|
| Sex: female | 0.763 (0.446–1.308) | 0.326 | ||
| Age: ≥70 years | 1.111 (0.671–1.840) | 0.683 | ||
| Pre-MDSC ratio: ≥22 % | 1.210 (0.698–2.096) | 0.497 | ||
| Pre-neutrophil | 0.990 (0.969–1.012) | 0.385 | ||
| Pre-lymphocyte | 1.014 (0.987–1.043) | 0.311 | ||
| Pre-neutrophil/lymphocyte | 0.978 (0.787–1.216) | 0.844 | ||
| Pre-ALT | 1.001 (0993–1.008) | 0.882 | ||
| Pre-serum albumin: <3.5 mg/dl | 1.143 (0.665–1.982) | 0.647 | ||
| Pre-prothrombin time: <70 % | 1.662 (0.961–2.903) | 0.073 | 1.881 (0.522–6.777) | 0.101 |
| Post-MDSC ratio: ≥22 % | 2.795 (1.150–6.792) | 0.023 | 3.906 (1.313–11.616) | 0.014 |
| Post-neutrophil | 1.005 (0.975–1.035) | 0.762 | ||
| Post-lymphocyte | 0.993 (0.960–1.027) | 0.678 | ||
| Post-neutrophil/lymphocyte | 1.003 (0.810–1.242) | 0.980 | ||
| Post-ALT | 0.995 (0.981–1.010) | 0.501 | ||
| Type IV collagen 7S | 1.122 (0.992–1.268) | 0.067 | 1.192 (0.907–1.566) | 0.207 |
| AFP: ≥100 ng/ml | 1.357 (0.743–2.480) | 0.321 | ||
| Tumor size: ≥20 mm | 1.29 (0.78–2.12) | 0.328 | ||
| Tumor multiplicity: multiple | 2.00 (1.18–3.40) | 0.010 | 1.851 (0.721–4.753) | 0.201 |
HR hazard ratio, CI confidence interval, ALT alanine aminotransferase, AFP alpha-fetoprotein