Fig. 3.

Tumor biology and auto-reactive immune responses. a Cellular autoimmunity and b humoral autoimmunity in relation to pathobiological features of the primary tumor. a Proportions of patients with auto-reactive TCs or b auto-reactive antibodies according to grading (G), hormone receptor expression (ER, PR), Her2/neu status, or stratified combinations of tumor differentiation and hormone receptor expression. Humoral autoimmunity was defined as at least one pathological finding within the tested antibodies (ANA, ANCA, TRAb, RhF, or TgAb). *Significant (P < 0.05) difference by Fisher’s exact test; n.s. not significant