Fig. 4.

Prognostic factors for time to next treatment and time to progression. To explore the prognostic role of the frequency and ratio (after 3 cycles to baseline) of cell populations for TTNT and TTP, the patients with continuous data were divided into two groups (low vs. high) by a ROC curve analysis. High ratio of $\text{CD}{3}_{\text{after}3\text{cycles/baseline}}^{+}$ (≥0.8) (a) and ${\text{CD8}}_{\text{after}3\text{cycles/baseline}}^{+}$ (≥0.6) (b) was associated with a longer TTNT. High frequency of NKT-like cells at baseline (≥1.26 %) was an independent factor for TTP (c)