Table 9.

Premanifest HD-0 (pre-0-HD) striatal projection neuron counts

Controls and Pre-0-HD: Mean SPN counts per 40× field, (SD), % of control, t-test p value
	Control	Pre-0-HD
Striosomes	25.73	15.76 (9.79) 61.3% p < 0.0001
Matrix	31.20	25.03 (8.66) 80.2% p < 0.0001

Total counts (number of fields) corrected number
Striosomes	1132 (44) 875	536 (34) 536
Matrix	2746 (88) 1061	1702 (68) 851
z-test: pre-0/control, striosomes versus matrix (corrected SPN numbers 851/1061 vs 536/875): z = 9.207, p < 0.0001, 95% confidence interval for difference between proportions: 0.148–0.229.

Dorsal vs ventral: Mean SPN counts per 40× field, (SD), % control, t-test p value
	Control	Pre-0-HD
Dorsal striosomes	28.70	12.20 (7.35) 42.5% p < 0.0001
Ventral striosomes	24.82	16.00 (11.4) 64.5% p < 0.03

Total counts (number of fields) corrected number
Dorsal striosomes	287 (10) 287	122 (10) 122
Ventral striosomes	422 (17) 248	143 (13) 110
z-test: pre-0/control, dorsal versus ventral striosomes: z = 4.806, p < 0.0001, 95% confidence interval for difference between proportions: 0.127–0.306.

	Control	Pre-0-HD
Dorsal matrix	30.43	21.14 (5.59) 69.5% p < 0.0001
Ventral matrix	34.20	29.59 (8.08) 86.5% p < 0.015

Total counts (number of fields) corrected number
Dorsal matrix	913 (30) 913	536 (30) 536
Ventral matrix	1744 (51) 1026	943 (34) 832
z-test: pre-0/control, dorsal versus ventral matrix: z = 10.794, p < 0.0001, 95% confidence interval for difference between proportions: 0.183–0.264.

SPN, striatal projection neuron.