Table 2.
Univariate and multivariate analyses of factors associated with survival
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| P value | HR | 95 % CI | P value | |
| Gender (male vs. female) | 0.838 | NA | ||
| Age, years (≥65 vs. <65) | 0.195 | NA | ||
| CEA,U/L (≥5 vs. <5) | 0.751 | NA | ||
| Tumor size, cm (≥5 vs. <5) | 0.550 | NA | ||
| H. pylori antibody (positive vs. negative) | 0.203 | NA | ||
| Histological type (differentiated vs. undifferentiated) | 0.755 | NA | ||
| Lymphatic invasion (positive vs. negative) | 0.555 | NA | ||
| Vascular invasion (positive vs. negative) | 0.152 | NA | ||
| Tumor (T) invasion (T1 + T2 vs. T3 + T4) | 0.941 | NA | ||
| Lymphoid nodal (N) status (N0 + N1 vs. N2 + N3) | 0.451 | NA | ||
| Distant metastasis (M) status (M0 vs. M1) | 0.883 | NA | ||
| TNM stage (I + II vs. III + IV) | 0.943 | NA | ||
| CD4+IL-22+ T-cell percentage (high vs. low)a | <0.001 | 1.654 | 1.242–2.204 | 0.001 |
| Th22-cell percentage (high vs. low)b | 0.045 | 0.524 | 0.245–1.122 | 0.096 |
Cox proportional hazards regression model. Variables used in multivariate analysis were adopted by univariate analysis
CEA carcinoembryonic antigen, HR hazard ratio, CI confidence interval, NA not adopted
aCD4+IL-22+ T-cell percentage was acquired on CD4+IL-22+cells in CD4+ T cells that gated on CD3+CD4+ cells of tumor tissues
bTh22-cell percentage was acquired on CD4+IL-22+IL-17−IFN-γ−cells in CD4+ T cells that gated on CD3+CD4+ cells of tumor tissues