Fig. 1.

NY-ESO-1-specific antibodies correlate with tumor load and disease progression while donor-derived anti-SSX-2 antibodies indicate disease remission. a Longitudinal analysis of humoral responses and antigen expression in the BM for individual patients. Black dots indicate reciprocal titers of anti-NY-ESO-1 and anti-SSX-2 antibodies. White dots indicate expression of NY-ESO-1 or SSX-2 RNA, and white triangles demonstrate expression of LAGE and SSX-4 RNA, respectively, in the BM of the patients. Within single graphs, white areas indicate the presence of clinical remission while gray areas indicate recurrence and progression of the disease. The application of alloSCT is indicated by small black arrows. b Comparison of means of reciprocal titer means for each patient during phases of the indicated clinical condition. Paired samples t tests indicate significant differences in antibody titers between clinical conditions for SSX-2 and NY-ESO-1