Table 2.
Correlations between TLR4, HBV, and severity of human RILD
| Severity of RILD | TLR4 expression by IHC-stained TMA | ||||
|---|---|---|---|---|---|
| RILD score (mean ± SEM) | p value | High TLR4 (cases) | Low TLR4 (cases) | p value | |
| HBV infection (n = 21/28) | 2.57 ± 0.24 | 0.55 | 8 | 13 | 1.00 |
| No HBV infection (n = 7/28) | 2.86 ± 0.34 | 3 | 4 | ||
| Low HBsAg on TMA (n = 19/28) | 2.68 ± 0.23 | 0.84 | 8 | 11 | 1.00 |
| High HBsAg on TMA (n = 9/28) | 2.6 ± 0.37 | 3 | 6 | ||
| HBV reactivation (n = 12/21) | 2.08 ± 0.31 | 0.02 | 2 | 10 | 0.03 |
| No HBV reactivation (n = 9/21) | 3.22 ± 0.28 | 6 | 3 | ||
| High TLR4 on TMA (n = 11/28) | 3.45 ± 0.25 | <0.01 | |||
| Low TLR4 on TMA (n = 17/28) | 2.12 ± 0.21 | ||||
RILD radiation-induced liver disease, TLR4 toll-like receptor 4, IHC immunohistochemistry, TMA tissue microarray, SEM standard error of the mean, HBV hepatitis B virus, HBsAg hepatitis B surface antigen