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Expression of an effector domain mutant of Rac that impairs cytoskeletal function but not JNK/MAP kinase activation inhibits Ad internalization. (A) SW480 cells were transiently transfected with a control plasmid, a wild-type Rac, or Rac mutants as indicated. Ad internalization was measured 45 h posttransfection. (B) Western blot of transfected cell lysates with an anti-c-Myc antibody. (C) JNK activation by transfected cells. Aniso, anisomycin.
