Table 2.
Modification of anti-tumour responses by B cell depletion
| Role of B cells | Model | B cell manipulation | Immune response | References |
|---|---|---|---|---|
| Positive | B16 melanoma | Acute anti-CD20 | Spontaneous | [34] |
| Positive | B16 melanoma | Acute anti-CD20 | Therapeutic inhibition of CD73 | [35] |
| Positive | GL26 glioblastoma | Acute anti-CD20 depletion before tumour challenge | AD-TK + Flt3L vaccination | [36] |
| Positive | FBL leukaemia | Chronic anti-IgM | Transfer of immune T cells | [29] |
| Negative |
AB12 mesothelioma TC1 and LKR lung cancer EL4 thymoma |
Acute anti-CD20 | Spontaneous | [38] |
| Negative | TC1 lung cancer | Acute anti-CD20 | Ad.E7 vaccination | [38] |