. 2015 Mar 21;64(6):727–736. doi: 10.1007/s00262-015-1679-3

Table 4.

PD-L1 expression and T cell infiltration in tumors before and after AdV-tk + prodrug

Dose level	Case #	PD-L1		CD4			CD8^a
Dose level	Case #	Pre	Post	Pre^a	Post^a	Fold change	Pre^a	Post^a	Fold change
1	1A03	−	++	0.67	1.67	2.49	4	31.33	7.83
2	2A02	−	++	4	9	2.25	1.67	55	32.93
3	3A01	+	+	1.33	0.33	0.25	1.67	125	74.85
3	3A02	+	+++	3	1.67	0.56	4.33	48.33	11.16
3	3A03	+	+++	9.67	7.33	0.76	8	98.33	12.29
4	4A01	+	+	8.33	5	0.60	6	39.33	6.56
4	4A02	−	+++	3.33	7.67	2.30	6.33	38	6.00
				Average CD4 change: 1.32			Average CD8 change: 21.66

^aAverage number of positive cells in three high-powered fields before (pre) or after (post) AdV-tk + prodrug