Fig. 3.

Treatment of cancer cell lines with 5-Aza -2′-Deoxycytidine increases expression of MHC class I but not costimulatory molecules. a MHC class I expression in the presence (dark line) and absence (dotted line) of 3 μM DAC. Cell lines were treated for 72 h and the filled histogram denotes an isotype control antibody. b Dose dependency of DAC treatment in BV173 cells. At 5 μM, the agent was cytotoxic and MHC I was not upregulated. c Failure of upregulation of the indicated surface molecules following 72 h treatment with 3 μM DAC. Data are representative of 3 independent experiments