Fig. 1.

Ra-224-loaded wire inhibits both DA3 and CT26 local tumor development. a DA3 tumor-bearing mice were treated with the intratumoral Ra-224-loaded wire (40–50 kBq/wire, n = 52) or with an inert wire (n = 46) or were left untreated. Tumor volumes were recorded for 14 days. P (T test) < 0.05 (except for day 0).b CT26 tumor-bearing mice were treated with the intratumoral Ra-224-loaded wire (40-50 kBq/wire, n = 17) or with an inert wire (n = 17). Tumor volumes were recorded for 14 days. P (T test) <0.05 (except for day 0). c Histological slices of DA3 tumors were taken 14 days, and CT26 tumors 5 days after a single Ra-224-loaded wire (half-life = 3.66 days)