Fig. 3.

DA3 tumor in mice upon the tumor ablation by Ra-224-loaded wires followed by subcutaneous administration of tumor cell. DA3 tumor-bearing mice were treated with intratumoral Ra-224-loaded wire (40–50 kBq/wire, n = 18) or with an inert wire (n = 24) followed by the removal of residual tumors at day 14 after the treatment. In some tumor-bearing mice, tumors were excised 14 days after wire insertion (surgery group; n = 26). Non-treated tumor-bearing mice served as a control (NT-TB; n = 7). The control and treated animals were challenged again s.c. with 5 × 10⁵ DA3 tumor cells 21 days after treatment. Naïve–Normal Balb/c mice that were injected only tumor cells at day 21 after the beginning of experiment (n = 25). P (two-way ANOVA without replication) <0.05, P (chi-square) <0.01 (days 10–15), P (chi-square) = 0.06 (days 20–33) (Ra-224-loaded wire vs. controls)