Fig. 5.

Effect of combined treatment on tumor development. Mice bearing breast DA3 tumors were treated with Ra-224-loaded wire (39.6–52.7 kBq/wire) combined with two injection of 100 µg CpG (Ra-224-loaded wire + CpG) (n = 11), with Ra-224-loaded wire only (Ra-224-loaded wire + PBS) (n = 9), with CpG alone (inert + CpG; n = 10) or left untreated (inert + PBS; n = 6). *P (T test) < 0.05 (on days: 2, 5, 21, and 39), P (two-way ANOVA w/o replication) <0.05 (Ra-224 load wires + CpG vs. controls, at all time points)