Table 5.
Chemokine receptors expressed by CTL020a | Chemokines | |
---|---|---|
Known to bind to receptor | Expressed by WC020b | |
CCR7 | CCL21 | +/− |
CCL19 | − | |
CCR9 | CCL25 | +/− |
CXCR3 | CXCL9 | +/− |
CXCL10 | − | |
CXCL11 | + | |
CXCL13 | − | |
CXCR4 | CXCL12 | − |
aThe following receptors were not expressed by CTL020: CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR8, CCR10, CCR11, CXCR1, CXCR2, CXCR5, CXCR6, CX3CR1
bChemokine expression was detected by RT-PCR. CXCL11 protein was detected in WC020 supernatant by ELISA (see Fig. 3a). CCL21, CCL25, and CXCL9 mRNA were detected in WC020 cells by RT-PCR, but the protein was not expressed as determined by ELISA