Table 1.

Immune defects in patients with CLL

Immune defect
Humoral defects
Hypogammaglobulinemia
Suppression of helper T-cells
IgA deficiency
IgG subset deficiency
Deficiencies in secondary antibody response
Cellular defects
T-cell subset imbalances
Suppressed helper T-cell function
Diminished T-cell response to proliferative signals
Suppressed NK cell function
Suppressed lymphocyte activated killer (LAK) cell function
Functional and maturation defects of dendritic cells
Decreased CD4 T-cell number with fludarabine therapy
Lymphopenia with alemtuzumab therapy
Neutropenia: disease-related and drug-induced
Deficiencies of complement system
Suppressed classical pathway components
Suppressed alternate pathway components