Fig. 3.

Lymphocytes from mice rendered resistant secrete IFN-γ, while mice suffering from progressive tumor growth predominately secrete IL-4, in response to tumor antigens. a Normal mice and mice made resistant to P815 by priming with 10⁵ P815 cells sc into their hind footpad were challenged 1 month after the sc priming with 10⁶ P815 cells id into their belly. The immune response was assessed 10 days post challenge. All normal mice had progressive tumor growth, and all primed mice appeared to be resistant at the time of killing. b Mice were implanted with 10⁶ L5178Y cells id into their belly on day 0. On day 30 of tumor growth when it became apparent which animals were successfully containing the tumor or suffering from progressive L5178Y growth, the spleens of the animals were collected and the immune response generated against the L5178Y tumor was assessed employing the ELISPOT assay