Fig. 7.
Induction of local and systemic antitumor immunity by administration of poly(I:C) and anti-CD40 plus OVA. a C57BL/6 mice were injected s.c. with 5 × 105 E.G7-OVA tumor cells in both flanks and when a tumor reached a diameter of 5–6 mm, this tumor was treated seven times with adjuvants plus OVA i.t. or with adjuvants i.t., but the tumor from the opposite flank was left untreated. Arrows indicate the days of administration. A control group including untreated mice was also followed. Graphs represent the evolution of tumor growth per mouse in the treated and untreated side. Numbers in each graph indicate tumor-free mice with respect to treated mice. b Survival of mice shown in a