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Effect of R-848 addition to cocultures of PBMC and AML cells. The concentration of IFN-γ detected in supernatant after 3 days of coculturing AML cells (AML), allogeneic PBMC, and/or R-848. The mean ± SD shown is of 3 independent experiments with AML cells from AML P21 (a) or NB-4 cells (b). −TW, without transwell; +TW, with transwell. * P < 0.05
