Fig. 5.

Effect of a low-dose metronomic TMZ regimen on tumor growth. Rats were inoculated with RG2 cells on day-12. Treatment, which consisted of vehicle alone (filled circles) or TMZ 0.5 mg/kg per day (open squares) was initiated on day 0. Tumor growth was assessed twice a week by size measurement with a calliper, and tumor volume was estimated using the standard formula: p/6 × length × width². Results are expressed as mean ± SEM of tumor volumes measured in 30 rats per group, by compilation of several experiments