Table 4.

Vaccination related immune response to p53 peptide 1–6 as evaluated by Elispot

Patient number	p53 peptide specific T cell reactivity (peptide number according to Table 1)
	Pre-existing	Induced	Increased	Reduced
Response at one evaluation
14	1,2,3,4	5,6	2,4
15		4,5,6
29		1,2,3,4,5,6
35		1,2,4
PD at 1.evaluation
13		1
27	3,4			3,4
36	1,2,3,4,6			1,2,3,4,6
38		1
Early termination
12	3,4,6	1,5	6
18	2,3,4,5,6	1	2,5,6

Elispot responses were defined as positive when the number of spots was >20 and more than 2 background (vehicle). Induced or increased responses was defined as responses >2 pre-vaccine levels, and reduced responses was defined as responses 2< prevaccine levels at a given time point. Data represents means of triplicates with background subtracted