Table 1.
Overall survival analysis of the top 50 genes positively and negatively correlated with ALDH2 in HCC.
| Pos Genes | HR | logrank P | Neg Genes | HR | logrank P |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 2 family member | 0.42 (0.29–0.6) | .00 | BCL2 antagonist/killer 1 | 1.88 (1.26–2.8) | .00 |
| solute carrier family 27 member 5 | 0.52 (0.36–0.74) | .00 | BEN domain containing 3 | 1.94 (1.34–2.82) | .00 |
| isovaleryl-CoA dehydrogenase | 0.47 (0.32–0.68) | .00 | RAD9-HUS1-RAD1 interacting nuclear orphan 1 | 1.81 (1.28–2.57) | .00 |
| phosphoenolpyruvate carboxykinase 2, mitochondrial | 0.54 (0.38– 0.77) | .00 | TOPBP1 interacting checkpoint and replication regulator | 1.95 (1.38–2.77) | .00 |
| acyl-CoA synthetase medium chain family member 2A | 0.5 (0.35–0.71) | .00 | suppressor APC domain containing 2 | 2.17 (1.52–3.09) | .00 |
| tetratricopeptide repeat domain 36 | 0.48 (0.32– 0.7) | .00 | caspase 2 | 1.89 (1.32–2.7) | .00 |
| lactate dehydrogenase D | 0.55 (0.38–0.8) | .00 | cell division cycle associated 4 | 2.07 (1.31–3.28) | .00 |
| enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase | 0.61 (0.42 –0.87) | .01 | cyclin dependent kinase 16 | 2.16 (1.53–3.06) | .00 |
| glycine-N-acyltransferase like 1 | 0.47 (0.32–0.7) | .00 | centromere protein A | 2.33 (1.65–3.29) | .00 |
| phosphatidylethanolamine binding protein 1 | 0.55 (0.38– 0.79) | .00 | centrosomal protein 55 | 2.62 (1.83–3.75) | .00 |
| 4-aminobutyrate aminotransferase | 0.49 (0.34–0.69) | .00 | CCR4-NOT transcription complex subunit 6 | 2.2 (1.52–3.17) | .00 |
| hydroxysteroid 17-beta dehydrogenase 6 | 0.48 (0.34–0.69) | .00 | DEP domain containing 1B | 2.14 (1.4–3.28) | .00 |
| alcohol dehydrogenase 1B (class I), beta polypeptide | 0.57 (0.4–0.81) | .00 | glucose-6-phosphate dehydrogenase | 2.52 (1.77–3.59) | .00 |
| methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | 0.63 (0.45–0.89) | .01 | GIT ArfGAP 1 | 1.98 (1.38–2.84) | .00 |
| glycine-N-acyltransferase like 1 | 0.58 (0.39–0.86) | .01 | glucosamine-6-phosphate deaminase 1 | 2.19 (1.54–3.13) | .00 |
| cytochrome b5 type A | 0.55 (0.38–0.8) | .00 | G2 and S-phase expressed 1 | 2 (1.41–2.85) | .00 |
| SEC14 like lipid binding 2 | 0.5 (0.35–0.71) | .00 | inhibitor of nuclear factor kappa B kinase subunit epsilon | 1.78 (1.16–2.72) | .01 |
| acyl-CoA synthetase medium chain family member 2B | 0.51 (0.35–0.74) | .00 | interleukin enhancer binding factor 3 | 1.55 (1.07–2.24) | .02 |
| dicarbonyl and L-xylulose reductase | 0.58 (0.4– 0.84) | .00 | kinesin family member 23 | 1.92 (1.36–2.71) | .00 |
| hydroxyacid oxidase 1 | 0.48 (0.32–0.73) | .00 | kinesin family member 2C | 2.4 (1.66–3.46) | .00 |
| dimethylglycine dehydrogenase | 0.47 (0.33–0.67) | .00 | La ribonucleoprotein 4B | 1.84 (1.25–2.71) | .00 |
| cytochrome P450 family 4 subfamily F member 2 | 0.56 (0.38–0.82) | .00 | ceramide synthase 5 | 1.81 (1.2–2.72) | .00 |
| coagulation factor XI | 0.45 (0.31–0.65) | .00 | LIM domain kinase 1 | 1.9 (1.34–2.69) | .00 |
| glyoxylate and hydroxypyruvate reductase | 0.55 (0.38–0.78) | .00 | lamin B2 | 1.77 (1.23–2.56) | .00 |
| alpha-2-glycoprotein 1, zinc-binding | 0.61 (0.43–0.86) | .00 | microtubule associated protein RP/EB family member 1 | 1.6 (1.12–2.29) | .01 |
| cytochrome P450 family 8 subfamily B member 1 | 0.6 (0.42–0.85) | .00 | mediator complex subunit 22 | 2.15 (1.51–3.07) | .00 |
| aspartate dehydrogenase domain containing | 0.47 (0.31–0.73) | .00 | major facilitator superfamily domain containing 10 | 1.63 (1.16–2.3) | .00 |
| hydroxyacylglutathione hydrolase | 0.45 (0.32–0.63) | .00 | myelin protein zero like 1 | 2.03 (1.37–2.99) | .00 |
| acetyl-CoA acetyltransferase 1 | 0.41 (0.29–0.59) | .00 | myotubularin related protein 2 | 2.39 (1.69–3.38) | .00 |
| malonyl-CoA decarboxylase | 0.66 (0.45–0.95) | .03 | MYB proto-oncogene like 2 | 2.29 (1.62–3.24) | .00 |
| enoyl-CoA hydratase domain containing 2 | 0.52 (0.37–0.74) | .00 | NDRG family member 3 | 1.83 (1.28–2.6) | .00 |
| sulfite oxidase | 0.45 (0.31–0.64) | .00 | phosphodiesterase 7A | 1.53 (1.08–2.16) | .02 |
| cell death inducing DFFA like effector b | 0.56 (0.39–0.79) | .00 | phosphatidylinositol glycan anchor biosynthesis class S | 1.71 (1.21–2.41) | .00 |
| catalase | 0.44 (0.3–0.65) | .00 | pyruvate kinase M2 | 2.07 (1.45–2.95) | .00 |
| tyrosine aminotransferase | 0.49 (0.35–0.7) | .00 | pleckstrin homology and RhoGEF domain containing G2 | 1.33 (0.94–1.88) | .11 |
| ATP binding cassette subfamily C member 6 | 0.45 (0.31–0.65) | .00 | plexin A1 | 1.98 (1.4–2.8) | .00 |
| cysteine dioxygenase type 1 | 0.51 (0.36–0.72) | .00 | PNMA family member 1 | 1.93 (1.36–2.72) | .00 |
| carboxypeptidase N subunit 2 | 0.53 (0.38–0.76) | .00 | regulator of chromosome condensation 2 | 2.22 (1.54–3.19) | .00 |
| complement C8 alpha chain | 0.59 (0.42–0.83) | .00 | ring finger protein 24 | 2 (1.42–2.84) | .00 |
| carboxylesterase 2 | 0.7 (0.48–1.02) | .06 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 1.63 (1.13–2.35) | .01 |
| glutaryl-CoA dehydrogenase | 0.48 (0.34–0.67) | .00 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 2.22 (1.53–3.22) | .00 |
| sterol carrier protein 2 | 0.51 (0.36–0.73) | .00 | SMYD family member 5 | 2.01 (1.41–2.86) | .00 |
| retinol binding protein 4 | 0.35 (0.25–0.5) | .00 | spermatogenesis associated serine rich 2 | 2.39 (1.68–3.39) | .00 |
| retinol binding protein 4 | 0.65 (0.46–0.91) | .01 | syntaxin 6 | 1.91 (1.34–2.73) | .00 |
| solute carrier family 10 member 1 | 0.46 (0.32–0.66) | .00 | transcription factor 3 | 1.56 (1.1–2.21) | .01 |
| methionine adenosyltransferase 1A | 0.59 (0.42–0.83) | .00 | TPD52 like 2 | 1.98 (1.4–2.8) | .00 |
| aquaporin 9 | 0.52 (0.36–0.75) | .00 | tripartite motif containing 59 | 1.64 (1.15–2.33) | .01 |
| apolipoprotein C4 | 0.52 (0.36–0.75) | .00 | TYRO3 protein tyrosine kinase | 1.88 (1.28–2.76) | .00 |
| speedy/RINGO cell cycle regulator family member C | 0.52 (0.36–0.75) | .00 | VPS37C subunit of ESCRT-I | 1.61 (1.14–2.28) | .01 |
| selenium binding protein 1 | 0.6 (0.42–0.85) | .00 | YEATS domain containing 2 | 2.23 (1.56–3.21) | .00 |