Fig. 3.

Implanted encapsulated hybridoma cells persist in their ability to secrete anti-CD137 mAb. Encapsulated hybridomas implanted as in Fig. 2 were surgically removed at days 4 and 10 post-implant. a Microphotographs obtained by phase-contrast microscopy of explanted capsules at the indicated days showing persistence of viable cells in their interior after seeded in culture (100 μL of capsules per mL of culture medium). b Concentration of rat IgG2a in the supernatant of the explanted capsule cultures assessed 48 h after culture initiation