Table 1.
HLA-A allele, gastric pathology and GCAA peptide reactivity of T cell clones generated from TILs isolated from the neoplastic tissue of gastric adenocarcinoma (GA) patients or from gastric mucosa-infiltrating T cells of patients with chronic gastritis (CG)
| Code | Sex/age | HLA-A allele | Gastric pathology | No. of clones obtained | |
|---|---|---|---|---|---|
| CD4+ | CD8+ | ||||
| No. of peptide-reactive clones | |||||
| 01.BB | 72 M | A02-A24 | Diffuse type GA | 0/15 | 0/10 |
| 02.CC | 66 M | A02-A24 | Diffuse type GA | 4/26 | 4/18 |
| 03.CA | 63 F | A02 | Diffuse type GA | 4/23 | 2/18 |
| 04.FM | 66 M | A02 | Diffuse type GA | 4/23 | 3/19 |
| 05.PF | 63 M | A24 | Diffuse type GA | 5/26 | 4/15 |
| 06.Can | 65 F | A24 | Diffuse type GA | 2/20 | 3/12 |
| 07.CS | 68 M | A24 | Diffuse type GA | 0/18 | 0/11 |
| 08.DN | 65 F | A24 | Diffuse type GA | 4/25 | 4/15 |
| 09.BG | 74 M | A02-A24 | Intestinal type GA | 3/27 | 4/19 |
| 10.BA | 74 M | A02-A24 | Intestinal type GA | 3/21 | 4/17 |
| 11.BS | 63 M | A02-A24 | Intestinal type GA | 4/24 | 3/14 |
| 12.BGi | 62 M | A02 | Intestinal type GA | 4/22 | 4/18 |
| 13.MS | 64 F | A02 | Intestinal type GA | 3/18 | 3/14 |
| 14.AC | 62 M | A02 | Intestinal type GA | 4/22 | 4/15 |
| 15.PM | 64 F | A02 | Intestinal type GA | 4/24 | 3/20 |
| 16.MG | 79 F | A02 | Intestinal type GA | 0/16 | 0/11 |
| 17.MM | 65 F | A02 | Intestinal type GA | 4/23 | 3/12 |
| 18.SB | 71 F | A24 | Intestinal type GA | 4/21 | 5/17 |
| 19.AB | 77 M | A24 | Intestinal type GA | 5/23 | 3/20 |
| 20.BF | 60 M | A24 | Intestinal type GA | 4/22 | 3/21 |
| All GA patients | 65/437 | 59/316 | |||
| 21.GG | 71 M | A02-A24 | Chronic gastritis | 0/17 | 0/7 |
| 22.CJ | 74 F | A02-A24 | Chronic gastritis | 0/15 | 0/6 |
| 23.BU | 71 M | A02-A24 | Chronic gastritis | 0/22 | 0/8 |
| 24.LL | 61 F | A02 | Chronic gastritis | 0/25 | 0/10 |
| 25.AG | 65 M | A02 | Chronic gastritis | 0/18 | 0/8 |
| 26.TS | 65 F | A02 | Chronic gastritis | 0/22 | 0/11 |
| 27.VA | 62 F | A02 | Chronic gastritis | 0/14 | 0/8 |
| 28.TF | 62 M | A02 | Chronic gastritis | 0/17 | 0/8 |
| 29.CZ | 62 F | A02 | Chronic gastritis | 0/15 | 0/6 |
| 30.PL | 59 M | A24 | Chronic gastritis | 0/22 | 0/11 |
| 31.SF | 75 M | A24 | Chronic gastritis | 0/20 | 0/9 |
| 32.ZF | 64 M | A24 | Chronic gastritis | 0/19 | 0/7 |
| 33.VV | 64 M | A24 | Chronic gastritis | 0/19 | 0/9 |
| 34.LS | 63 M | A24 | Chronic gastritis | 0/21 | 0/8 |
| 35.PO | 62 F | A24 | Chronic gastritis | 0/16 | 0/4 |
| All CG patients | 0/282 | 0/120 | |||
GA gastric adenocarcinoma