Table 4.
Effect of anti-HLA class I and II monoclonal antibodies on T cell clone proliferation induced by GCAA peptides
| Phenotype of clones/specific peptides | Peptide alone (MI ± SD) | Peptide + anti-HLA class I (% inhibition) | Peptide + anti-HLA class II (% inhibition) |
|---|---|---|---|
| Culture conditions | |||
| CD4+/SART2-93 | 51.7 ± 5.2 | 8.2 ± 1.2 (84) | 42.5 ± 3.2 (18) |
| CD4+/lck-208 | 63.4 ± 4.1 | 7.7 ± 3.1 (88) | 54.3 ± 5.4 (14) |
| CD4+/lck-488 | 72.6 ± 3.4 | 56.6 ± 7.4 (12) | 13.7 ± 2.2 (81) |
| CD4+/ART4-13 | 52.3 ± 3.7 | 14.2 ± 2.3 (73) | 41.1 ± 9.1 (21) |
| CD4+/HNRPL-501 | 57.2 ± 8.5 | 49.7 ± 5.2 (13) | 11.2 ± 1.5 (80) |
| CD4+/UBE2V-43 | 62.3 ± 2.5 | 12.4 ± 4.3 (80) | 47.7 ± 8.7 (13) |
| CD8+/SART2-93 | 35.3 ± 5.3 | 4.7 ± 1.2 (87) | 27.1 ± 6.3 (13) |
| CD8+/lck-208 | 42.5 ± 6.1 | 5.2 ± 0.8 (88) | 37.4 ± 7.2 (12) |
| CD8+/lck-486 | 26.7 ± 4.3 | 4.5 ± 3.2 (83) | 21.5 ± 6.1 (19) |
| CD8+/CypB-172 | 33.5 ± 3.8 | 8.3 ± 1.2 (75) | 29.5 ± 4.8 (12) |
| CD8+/WHSC2-103 | 56.4 ± 5.1 | 11.6 ± 5.2 (79) | 48.7 ± 5.7 (14) |
| CD8+/HNRPL-501 | 47.3 ± 5.6 | 6.7 ± 1.1 (76) | 38.9 ± 3.9 (18) |
MI mitogenic index, SD standard deviation