Fig. 5.

Paclitaxel induced higher recruitment into tumor and a higher proportion of CD62^lo cells in spleen for tumor antigen-specific CD8⁺ T cells. a Percentage of OT-1 cells recovered from tumors 3 days after adoptive transfer and 5 days after treatment with PBS (closed circles), peritumoral PF-3512676 (open circles), IP paclitaxel (closed diamonds) or both (open diamonds). Results are expressed as individual data and mean and are cumulative of three independent experiments. b Percentage of CD62^lo cells within adoptively transferred OT-1 cells in spleen from EG.7 tumor-bearing mice 3 days after transfer and 5 days after treatment with PBS (white bars), peritumoral PF-3512676 (black bars), IP paclitaxel (gray bars) or both (hatched bars). Results are representative of three independent experiments (n = 5 per experiment). c Percentage of CD62^lo cells within normal mouse spleen CD8⁺ T cells 48 h after treatment with PBS (white bars) or anti-CD25 antibody (black bars). Results are representative of two independent experiments (n = 5 per experiment). Statistical analyses: Mann–Whitney test