Fig. 6.

Modification of gene expression induced by paclitaxel and/or PF-3512676 in tumor bearing mice. Gene expression analyses were performed by real-time RT-PCR in tumors (left panels) and tumor-draining lymph nodes (right panels) 24 h after a second cycle of treatment with IP paclitaxel and peritumoral PF-3512676 and results calculated as fold expression relative to the indicated controls as outlined in "Materials and methods". Results combined nine different tumors from three independent experiments and six lymph nodes from two independent experiments. From all genes analyzed (Table 1), only those expressed (mean) at least threefold higher (black bars) or threefold lower (gray bars) compared to their respective controls are represented. a Gene expression in PF-3512676-treated mice compared to PBS-treated mice. b Gene expression in paclitaxel-treated mice compared to PBS-treated mice. c Gene expression in paclitaxel plus PF-3512676-treated mice compared to PBS-treated mice. d Gene expression in paclitaxel plus PF-3512676-treated mice compared to PF-3512676-treated mice