Fig. 4.

NK depletion reverses tumor growth inhibition conferred by osteomyelitis. Mice (n = 5 per group) were challenged with infections and tumors as previously described. Three days after tumor challenge, mice were treated with an anti-asialo GM1 antibody administered IP to deplete NK cells, and treatment was repeated weekly. There was significant (*p < 0.05) growth inhibition in the infected tumor-bearing mice when compared to the uninfected mice and the NK-depleted infected mice as measure by repeated measures one-way ANOVA with Bonferroni post-test. NK-depleted infected mice did not have a significantly (p > 0.05) different growth when compared to tumor only mice. Results are representative of two independent experiments