Fig. 7.

Monocyte depletion abolishes the inhibitory effects of osteomyelitis on tumor growth. C3H mice (n = 5 per groups) were infected and challenged with tumors as described in the Materials and methods. Mice were administered liposomal clodronate (LC) IV 3 days after tumor challenge and then weekly thereafter. a Flow cytometry was performed to determine the concentration of monocytes in circulation as described in the Materials and methods. There was a significant (**p < 0.01, *p < 0.05) depletion of monocytes in the mice receiving LC compared to all other groups as determined by one-way ANOVA with Bonferroni post-test. b Infected mice had significantly decreased tumor growth (*p < 0.05) when compared to uninfected mice and infected mice receiving LC by repeated measures one-way ANOVA with Bonferroni post-test. There was no statistical difference (p > 0.05) between infected mice treated with LC and uninfected tumor-bearing mice