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E-selectin expression is inhibited by the PKC inhibitor bisindolylmaleimide-1. EC were treated with PEP005 in the presence of a number of PKC and MAP kinase inhibitors. Only bisindolylmaleimide 1 consistently reduced the expression E-selectin mRNA as assessed by TaqMan PCR. Data are mean ± SEM of five experiments; **P < 0.01 by t test for comparison of PEP005 treated cells in the presence or absence of PKC inhibitors
