Cytokine production by T cells of patients and healthy controls. Percentage of IFN-γ (a), IL-4 (b), IL-2 (c) producing CD4 T cells in breast cancer patients who had received prior adjuvant radiotherapy (RT) (n = 20) (filled square), radio-chemotherapy (RT + CT) (n = 21) (filled diamond) and in normal healthy controls (NC) (n = 11) (filled triangle). Data at each time point is shown as mean ± SEM. † Significant P value for repeated measurements ANOVA, comparing two groups of patients at four different time points. * Significant P value for ANOVA with Post Hoc test, comparing healthy controls and patients at three different time points. Differences were considered to be statistically significant if P was less than or equal to 0.05