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[Preprint]. 2024 Apr 11:2023.09.27.559826. [Version 2] doi: 10.1101/2023.09.27.559826

Figure 2: Fitness values provide structural, functional and evolutionary insights in rubisco.

Figure 2:

A) Structure of R. rubrum rubisco homodimer (Protein Data Bank (PDB) ID: 9RUB) colored by the average fitness value of a substitution at every site. B) Histograms of variant effects for amino-acids in different parts of the homodimer complex. C) Comparison of average fitness at each position against phylogenetic conservation among all rubiscos. Positions colored by the same scheme as part B. Positions 215 and 257 form a tertiary interaction, position 186 is highly conserved with no known function. D) Close-up view of the active-site and the mobile loop 6 region. Radar plots show the fitness effects of all mutations at a given position.