Table 5.
Patients | Total TIL (10−9)b | Melan-A specific TIL (10−6)c | Melan-A26–35 reactive lymphocytes (10−6)d |
---|---|---|---|
Melan-A/A2 specific TIL (n = 14) | |||
RF-patients | |||
M117 | 33.4 | 2,200 | 534 |
M182 | 3.7 | 740 | 252 |
M278 a | 13.2 | 475 | 211 |
M134 | 22.5 | 450 | 270 |
M170a | 9.5 | 190 | 38 |
M180a | 9 | 180 | 54 |
M254 a | 3.3 | 109 | 53 |
R-patients | |||
M171 | 22 | 3,740 | 1,892 |
M199 | 8.3 | 556 | 108 |
M113 | 21.2 | 360 | 85 |
M263 a | 12.6 | 315 | 101 |
M131 | 15.5 | 93 | 46 |
M204 | 26 | 52 | 26 |
M275a | 9.2 | 37 | 28 |
aMelanoma patients bearing only one invaded lymph node
bTotal amount of TIL infused to patients
cEstimated amount of Melan-A specific TIL infused (detected by tetramer labeling). Patients indicated in italics have been patients enrolled in the open study
dEstimated amount of infused Melan-A26–35 reactive lymphocytes (detected by IFN-γ intracellular labeling in response to peptide pulsed-T2 cells)