Fig. 6.

The effects of IFNγ on AML cell release of angioregulatory chemokines. The figure presents the proangiogenic CXCL8 and antiangiogenic CXCL9, CXCL10 and CXCL11 concentrations in supernatants for AML cells from 67 consecutive patients. The cells were cultured for 48 h either in medium alone (−) or in the presence of IFNγ 50 ng/ml (+). Chemokine levels were determined by ELISA analyses. Line denotes the median. IFNγ increased CXCL8 levels and decreased CXCL9–11 levels (P=0.0004 for CXCL8, P<0.0001 for CXCL9, P<0.0001 for CXCL10 and P<0.0001 for CXCL11)