. 2007 Aug 4;57(3):379–388. doi: 10.1007/s00262-007-0377-1

Table 2.

GM-CSF peak serum concentration (median, range) at days 1 and 10 of treatment cycle I, as well as of all patients treated with a high or a low dose of GM-CSF regardless of treatment cycle number

Patient category	No.of pairs	GM-CSF concentration (pg/ml)				Statistics P-value
		Day 1		Day 10
		Median	Range	Median	Range
Patients in treatment cycle I	15	6240.0	273.3–11426.6	2301.6	13.1–8620.0	0.003^a
High dose patients irrespective of cycle (≥200 μg/m²/day)	12	8850.1	2826.2–14720.0	3388.3	953.0–9620.5	0.005^a
High dose patients irrespective of cycle (≥200 μg/m²/day)	12	8850.1	2826.2–14720.0	3388.3	953.0–9620.5	0.05^b
Low dose patients irrespective of cycle (<200 μg/m²/day)	7	1235.0	273.0–2753.4	547.0	5.9–5627.3	0.04^a

^aWilcoxon signed rank test comparing days 10 and day 1

^bMann–Whitney U-test comparing days 10 and 1 of patients in the high or low GM-CSF dose, respectively