Figure 2. Altered levels of stress signaling and circadian clock proteins in subjects with bipolar disorder.

(A) Whisker plots depicting significantly greater SST serum protein levels (A), and lower serum protein levels of CRH (B) in subjects with BD compared to control subjects. No difference was detected for serum levels of the core clock protein PER2 (C) whereas levels of the core clock protein ARNTL were significantly lower in subjects with BD (D). Protein values represent pg/ml for SST and CRH and ng/ml for PER2 and ANRTL.