Figure 4: Outbreak investigation pairing WGS of methicillin susceptible Staphylococcus aureus isolates and mNGS of surveillance skin swabs from babies in a neonatal intensive care unit.

(A) Unsupervised clustering of AMR gene profiles from WGS data reveals a cluster of related isolates indicated by the dashed-line box. (B) Matrix of single nucleotide polymorphism (SNP) distances between each sequenced isolate confirms the genetic relatedness of this cluster, which is highlighted by a dashed-line box.