Extended Data Figure 8. TC83 E1 SNPs are conserved in other epizootic strains and are lineage specific.
Dot plots from RNAfold [17] predictions of individual SNPs within the E1 core region (10,466–10,843) for (A) TC83, (B) TC83/E1ID-syn and (C) overlayed dotblots. Yellow boxes highlight regions with differences in RNA structure predictions. (D) Predicted RNA secondary structures from RNA alignfold [41]of sequences from lineages K (divided into epizootic IC and enzootic ID), L and M. Steml-oop conserved in epizootic lineages is highlighted in blue, and stem-loop conserved in all lineage K and L highlighted in grey.