Fig. 2.

Treatment of mice with anti-CD137 mAb causes increases in transaminases and moderate hepatocyte apoptosis. a Sequential serum samples were collected from mice treated as in Fig. 1 and the concentration of SGOT and SGPT are given on day 14 when these parameters peaked. This experiment is representative of two similarly performed experiments. b Tunel staining of liver sections from the indicated mice as in a are shown. Arrows indicate fluorescence in the apoptotic nuclei