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High dosage CTX (200 mg/day) metronomic treatment looses its specificity in Treg cell depletion. a Lymphocyte, CD3+CD4+ and CD3+CD8+ lymphocytes, and CD3-CD56+ NK cells absolute numbers were determined before and 1 month after initiating high dosage CTX metronomic treatment. b Effect on the CD3+CD4+CD25high Treg. Statistical analyses used the Fisher’s exact method
