Fig. 2.

ADCC and CDC against NXS2 neuroblastoma mediated by sera of mice (n = 4) immunized with the 47-LDA construct in the presence, absence or combination of IL-15 and IL-21 genes. a ADCC against NXS2 cells was measured using sera from mice immunized with the 47-LDA vaccine in the presence, absence or combination of IL-15 and IL-21 genes (solid symbols) or from the sham plasmid-immunized counterparts (open symbols). b The complement-mediated lysis of NXS2 was determined using the same sera from 47-LDA-immunized (black symbols) and sham plasmid-immunized (open symbols) mice. All determinations were made in triplicate samples, and the SD was <10%. Results are presented as the means ± SD (error bars) of four independent experiments