Fig. 4.

Cytokine and perforin production by CD4⁺ and CD8⁺ cells in TIL and NIL as determined by intracellular staining. The percentage of cytokine- or perforin-producing CD4⁺ or CD8⁺ cells in TIL and NIL are shown for individual patients. *P < 0.05, **P < 0.01