Fig. 3.

Murine MM, combined subcutaneous growth: Combined group C11C1 and B38 (gray hexagons) received C11C1-MM and B38-MM cells which were implanted together in the back of Balb/c mice (n=5) to monitor their growth. Group B38 (open circles) (n=5) and group C11C1 (solid circles) (n=5) received either B38-MM or C11C1-MM cells (implanted in the back of Balb/c mice) and were used to monitor their separate growth rate in vivo. There were no significant differences up to and included day 26 between the combined group and the B38 group. At day 28 and beyond the B38 group showed a statistically significant increase in volume when compared to the combined group (P<0.05). The B38 group tumor volume was significantly larger than the C11C1 group from day 10 and beyond (P<0.05). Values shown are mean ± SEM.