Fig. 3.
Some of the CD8+ T cells in the FVB/N HER-2/neu transgenic mouse are of lower avidity than the cells from wild type FVB/N mice. CTL analysis of each of the epitopes using decreasing concentrations of the peptide pulsed onto 3T3-wt target cells. The concentrations used were 10−6, 10−7, 10−8, 10−9, 10−10 M. Wild type and transgenic mice are directly compared at a 200:1 E:T ratio. a PDSLRDLSVF, b PYNYLSTEV, c LFRNPHQALL, d PGPTQCVNCS, e PNQAQMRIL, f GSGAFGTVYK, g AFGTVYKGI, h PYVSRLLGI, and i LQRYSEDPTL