Table 1.

Avidity of HER-2/neu specific CD8⁺ T cells in the FVB/N HER-2/neu transgenic mice versus wild type FVB/N mice

Vaccine	Epitope	AA region	MHC class I	Wild type mice (nM)	Transgenic mice (nM)	Log difference
Lm-LLO-EC1	PYNYLSTEV	302–310	H-2Kq	1	8	0.9
Lm-LLO-EC2	PDSLRDLSVF	420–429	H-2 Dq	0.5	10	1.3
	LFRNPHQALL	489–498	H-2Kq	5	7	0.15
Lm-LLO-EC3	PGPTQCVNCS	528–537	H-2Dq	1	30	1.48
Lm-LLO-IC1	PNQAQMRIL	712–720	H-2Dq	0.5	20	1.6
	GSGAFGTVYK	732–741	H-2Dq	1	10	1
	AFGTVYKGI	735–743	H-2Kq	5	8	0.2
	PYVSRLLGI	785–793	H-2Kq	8	8	0
Lm-LLO-IC2	LQRYSEDPTL	1,114–1,123	H-2Dq	1	10	1

Each epitope is shown with the peptide concentration at which the percent specific lysis drops to a level 50% lower than initially seen at a high peptide concentration of 1,000 nM. The epitopes are shown with the corresponding vaccine, the amino acid region that delineates each epitope, the MHC class I restriction, and the log difference of the CD8⁺ T cells that respond to each epitope in the wild type versus the transgenic mouse