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X-ray structure of humanized 2C4 Fab (pertuzumab) [48] (PDB accession number 1L71). The CDR loops of the light (L1-3) and heavy chains (H1-3) are indicated. Side chains of VH residues that were investigated or changed during humanization are shown (refer to Table 1 for details for specific changes and their effect on binding relative to the chimera)
