Table 4.
MDX-447 pharmacokinetic parameters
| Dose (mg/m2) | Group 1 | Group 2 | ||||
|---|---|---|---|---|---|---|
| C max (μg/ml) | AUC (μg ml/h) | T1/2 (h) | C max (μg/ml) | AUC (μg ml/h) | T1/2 (h) | |
| 1.0 | ||||||
| Mean (n) | 0.28 | 0.67 | 3.15 | 0.24 | 0.60 | 1.92 |
| SD | 0.21 | 0.45 | 2.90 | 0.10 | 0.20 | 1.21 |
| N | 14 | 14 | 12 | 4 | 4 | 3 |
| 3.5 | ||||||
| Mean (n) | 1.02 | 4.70 | 2.40 | 0.83 | 4.33 | 1.86 |
| SD | 0.83 | 4.30 | 1.16 | 0.34 | 1.60 | 0.54 |
| N | 12 | 12 | 10 | 13 | 13 | 11 |
| 7.0 | ||||||
| Mean (n) | 1.48 | 11.60 | 4.55 | 2.02 | 9.07 | 3.12 |
| SD | 0.37 | 3.35 | 1.69 | 2.15 | 3.86 | 1.03 |
| N | 8 | 8 | 8 | 10 | 10 | 8 |
| 10.0 | ||||||
| Mean (n) | 3.01 | 34.92 | 5.91 | 1.50 | 14.78 | 4.95 |
| SD | 2.38 | 37.79 | 3.74 | 0.90 | 14.50 | 6.74 |
| N | 7 | 7 | 6 | 12 | 12 | 8 |
| 15.0 | ||||||
| Mean (n) | 2.87 | 38.00 | 8.22 | 1.46 | 13.46 | 5.63 |
| SD | 1,22 | 20.94 | 6.61 | 0.54 | 8.69 | 4.39 |
| N | 15 | 15 | 10 | 4 | 4 | 4 |
| 20.0 | ||||||
| Mean (n) | 3.71 | 42.05 | 7.06 | |||
| SD | 1.09 | 20.58 | 3.36 | |||
| N | 13 | 14 | 10 | |||
| 30.0 | ||||||
| Mean (n) | 5.57 | 70.15 | – | |||
| SD | 2.98 | 40.60 | – | |||
| N | 14 | 14 | – | |||
| 40.0 | ||||||
| Mean (n) | 13.96 | 185.54 | 8.37 | |||
| SD | 4.51 | 90.54 | 1.05 | |||
| N | 7 | 7 | 5 | |||
N number of drug administrations studied, SD standard deviation