Table 5.

MDX-447 bound to neutrophils (mean % positive), day 1

Dose of MDX-447 (mg/m2)	Hours post-initiation of MDX-447 infusion
	0	2	4	6	24
Group 1
1.0	2	1	2	1	2
3.5	6	20	12	18	18
7.0	2	11	16	38	38
10.0	1	17	18	41	19
15.0	13	13	22	15	30
20.0	2	7	8	6	15
30.0	3	14	23	25	32
40.0	2	5	11	22	59
Group 2
1.0 + G-CSF	1	40	18	10	1
3.5 + G-CSF	12	95	92	86	47
7.0 + G-CSF	3	70	92	99	65
10.0 + G-CSF	8	95	94	88	66
15.0 + G-CSF	1	97	98	88	64